Polyrotaxane-containing hydrogels for label-free detection of C-reactive protein (CRP) via diffraction gratings
Polyrotaxane-containing hydrogels for label-free detection of C-reactive protein (CRP) via diffraction gratings Aitor Cubells-Gómez, María Isabel Lucío, Ángel Maquieira, María-José Bañuls Sensing and Bio-Sensing Research, 2025, 49, 100849.https://doi.org/10.1016/j.sbsr.2025.100849.
Harmonia Project at the First Scientific Symposium of the National Consortium on Nanoscience and Analytical Nanotechnology (NyNA)

Harmonia Project at the First Scientific Symposium of the National Consortium on Nanoscience and Analytical Nanotechnology (NyNA) Harmonia Project was present at the First Scientific Symposium of the National Consortium on Nanoscience and Analytical Nanotechnology (NyNA) held in the emblematic teaching center “La Cristalera” from the Autonomous University of Madrid in Miraflores de la Sierra (Madrid) during the 22nd and 23rd of July. We are very grateful for the opportunity to share our latest advancements on the development of hydrogels for wearable biosensing and discuss their promising and versatile applications with the best analytical chemistry experts from all over Spain.
Surface Relief Gratings of Slide-Ring Hydrogels for Label-Free Biosensing
Surface Relief Gratings of Slide-Ring Hydrogels for Label-Free Biosensing Aitor Cubells-Gómez, María Isabel Lucío, María-José Bañuls, Ángel Maquieira Gels 2025, 11(6), 415 https://doi.org/10.3390/gels11060415
First article published with the progress of HARMONIA

First publicatioin derived from HARMONIA We have published the first article resulting from the advances made at HARMONIA. In this work, we developed biofunctional hydrogels that integrate supramolecular slip-ring structures. These materials offer improved selectivity and sensitivity in the detection of biomolecules, such as bovine serum albumin and rabbit IgG antibodies, without the need of labels. The hydrogels exhibit superior mechanical characteristics, with durability and elasticity comparable to human skin. Furthermore, their flexibility allows the recognition elements to be adapted to various applications. We invite you to read the full article to learn more about these advances in holographic biosensing.
Advances in the HARMONIA Project Presented by Aitor Cubells at the SPIE Optics + Optoelectronics Conference

Advances in the HARMONIA Project Presented by Aitor Cubells at the SPIE Optics + Optoelectronics Conference We are pleased to announce that Aitor Cubells Gómez, a SYM group researcher at the Interuniversity Institute for Molecular Recognition and Technological Development (IDM), Polytechnic University of Valencia (UPV), recently participated in the international conference SPIE Optics + Optoelectronics, held in Prague. This event is one of the most important global gatherings in the field of optics and optoelectronics. Aitor presented his work carried out within the HARMONIA project, part of the PROMETEO program from the Generalitat Valenciana, and during his doctoral stay at the Centre for Industrial and Engineering Optics at the Technological University of Dublin (TU Dublin). His production, entitled “Advanced Hydrogel-Based Volume Holographic Gratings for Label-Free Biosensing”, was carried out in an oral presentation session and generated great interest among the attendees, highlighting the innovation and potential of his research in the field of molecular recognition and biosensor development. Participation in SPIE Optics + Optoelectronics has been a valuable opportunity to share the project’s progress and make new contacts.
The SYM Group presents its advances at Biosensors 2025

The SYM Group presents its advances at Biosensors 2025 Members of the SYM group recently participated in Biosensors 2025, one of the most prestigious international conferences in the field of sensors and biosensors. During the event, researchers presented the latest advances of the HARMONIA project through an oral presentation and several scientific posters, which generated considerable interest among attendees. Participation in Biosensors 2025 was an excellent opportunity to show the innovative work being carried out by the HARMONIA project to the international scientific community, as well as to foster new collaborations and explore future lines of research in the field of molecular recognition and sensor development.